The role of N-glycosylation in kiwi allergy.
Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161The role of N-glycosylation in kiwi allergy.
Auteurs : María Garrido-Arandia [Espagne] ; Amaya Murua-García [Espagne] ; Aranzazu Palacin [Espagne] ; Leticia Tordesillas [Espagne] ; Cristina G Mez-Casado [Espagne] ; Natalia Blanca-Lopez [Espagne] ; Tania Ramos [Espagne] ; Gabriela Canto [Espagne] ; Carlos Blanco [Espagne] ; Javier Cuesta-Herranz [Espagne] ; Rosa Sánchez-Monge [Espagne] ; Luis F. Pacios [Espagne] ; Araceli Díaz Perales [Espagne]Source :
- Food science & nutrition [ 2048-7177 ] ; 2014.
Abstract
The physical, biochemical, and immunological characteristics of plant allergens have been widely studied, but no definite conclusion has been reached about what actually makes a protein an allergen. In this sense, N-glycosylation is an exclusive characteristic of plant allergens not present in mammals and it could be implied in allergenic sensitization. With this aim, we evaluated and compared the allergenic activity of the protein fraction and the N-glycan fraction of the thaumatin-like protein and the main kiwi allergen, Act d 2. The natural allergen, Act d 2, was deglycosylated by trifluoromethanesulfonic acid treatment; the N-glycan fraction was obtained by extended treatment with proteinase K. N-glycan- and protein- fractions were recognized by specific IgE of kiwi-allergic patients. By contrast, the sugar moiety showed a reduced capacity to activate basophils and T cells, but not dendritic cells derived from patients' monocytes. Related to this, the production of cytokines such as IL6 and IL10 was increased by the incubation of dendritic cells with sugar moiety. Thus, the sugar moiety plays a significant role in sensitization, inducing the activation of antigen-presenting cells, but it is the protein fraction that is responsible for the allergic reactions.
DOI: 10.1002/fsn3.99
PubMed: 24936296
PubMed Central: PMC4048612
Affiliations:
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I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Murua Garcia, Amaya" sort="Murua Garcia, Amaya" uniqKey="Murua Garcia A" first="Amaya" last="Murua-García">Amaya Murua-García</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Palacin, Aranzazu" sort="Palacin, Aranzazu" uniqKey="Palacin A" first="Aranzazu" last="Palacin">Aranzazu Palacin</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Tordesillas, Leticia" sort="Tordesillas, Leticia" uniqKey="Tordesillas L" first="Leticia" last="Tordesillas">Leticia Tordesillas</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="G Mez Casado, Cristina" sort="G Mez Casado, Cristina" uniqKey="G Mez Casado C" first="Cristina" last="G Mez-Casado">Cristina G Mez-Casado</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Blanca Lopez, Natalia" sort="Blanca Lopez, Natalia" uniqKey="Blanca Lopez N" first="Natalia" last="Blanca-Lopez">Natalia Blanca-Lopez</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Service, Hospital Infanta Leonor Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Allergy Service, Hospital Infanta Leonor Madrid</wicri:regionArea><wicri:noRegion>Hospital Infanta Leonor Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Ramos, Tania" sort="Ramos, Tania" uniqKey="Ramos T" first="Tania" last="Ramos">Tania Ramos</name><affiliation wicri:level="1"><nlm:affiliation>Health Research Institute La Princesa (IP) Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Health Research Institute La Princesa (IP) Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Canto, Gabriela" sort="Canto, Gabriela" uniqKey="Canto G" first="Gabriela" last="Canto">Gabriela Canto</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Service, Hospital Infanta Leonor Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Allergy Service, Hospital Infanta Leonor Madrid</wicri:regionArea><wicri:noRegion>Hospital Infanta Leonor Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Blanco, Carlos" sort="Blanco, Carlos" uniqKey="Blanco C" first="Carlos" last="Blanco">Carlos Blanco</name><affiliation wicri:level="1"><nlm:affiliation>Health Research Institute La Princesa (IP) Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Health Research Institute La Princesa (IP) Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Cuesta Herranz, Javier" sort="Cuesta Herranz, Javier" uniqKey="Cuesta Herranz J" first="Javier" last="Cuesta-Herranz">Javier Cuesta-Herranz</name><affiliation wicri:level="1"><nlm:affiliation>IIS-Allergy Service, Fundación Jiménez Díaz Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>IIS-Allergy Service, Fundación Jiménez Díaz Madrid</wicri:regionArea><wicri:noRegion>Fundación Jiménez Díaz Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Monge, Rosa" sort="Sanchez Monge, Rosa" uniqKey="Sanchez Monge R" first="Rosa" last="Sánchez-Monge">Rosa Sánchez-Monge</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pacios, Luis F" sort="Pacios, Luis F" uniqKey="Pacios L" first="Luis F" last="Pacios">Luis F. Pacios</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain ; Biotechnology Department, ETSI de Montes, Technical University Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain ; Biotechnology Department, ETSI de Montes, Technical University Madrid</wicri:regionArea><wicri:noRegion>Technical University Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Perales, Araceli" sort="Diaz Perales, Araceli" uniqKey="Diaz Perales A" first="Araceli" last="Díaz Perales">Araceli Díaz Perales</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">Food science & nutrition</title><idno type="ISSN">2048-7177</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The physical, biochemical, and immunological characteristics of plant allergens have been widely studied, but no definite conclusion has been reached about what actually makes a protein an allergen. In this sense, N-glycosylation is an exclusive characteristic of plant allergens not present in mammals and it could be implied in allergenic sensitization. With this aim, we evaluated and compared the allergenic activity of the protein fraction and the N-glycan fraction of the thaumatin-like protein and the main kiwi allergen, Act d 2. The natural allergen, Act d 2, was deglycosylated by trifluoromethanesulfonic acid treatment; the N-glycan fraction was obtained by extended treatment with proteinase K. N-glycan- and protein- fractions were recognized by specific IgE of kiwi-allergic patients. By contrast, the sugar moiety showed a reduced capacity to activate basophils and T cells, but not dendritic cells derived from patients' monocytes. Related to this, the production of cytokines such as IL6 and IL10 was increased by the incubation of dendritic cells with sugar moiety. Thus, the sugar moiety plays a significant role in sensitization, inducing the activation of antigen-presenting cells, but it is the protein fraction that is responsible for the allergic reactions. </div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24936296</PMID><DateCompleted><Year>2014</Year><Month>06</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2048-7177</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Food science & nutrition</Title><ISOAbbreviation>Food Sci Nutr</ISOAbbreviation></Journal><ArticleTitle>The role of N-glycosylation in kiwi allergy.</ArticleTitle><Pagination><MedlinePgn>260-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/fsn3.99</ELocationID><Abstract><AbstractText>The physical, biochemical, and immunological characteristics of plant allergens have been widely studied, but no definite conclusion has been reached about what actually makes a protein an allergen. In this sense, N-glycosylation is an exclusive characteristic of plant allergens not present in mammals and it could be implied in allergenic sensitization. With this aim, we evaluated and compared the allergenic activity of the protein fraction and the N-glycan fraction of the thaumatin-like protein and the main kiwi allergen, Act d 2. The natural allergen, Act d 2, was deglycosylated by trifluoromethanesulfonic acid treatment; the N-glycan fraction was obtained by extended treatment with proteinase K. N-glycan- and protein- fractions were recognized by specific IgE of kiwi-allergic patients. By contrast, the sugar moiety showed a reduced capacity to activate basophils and T cells, but not dendritic cells derived from patients' monocytes. Related to this, the production of cytokines such as IL6 and IL10 was increased by the incubation of dendritic cells with sugar moiety. Thus, the sugar moiety plays a significant role in sensitization, inducing the activation of antigen-presenting cells, but it is the protein fraction that is responsible for the allergic reactions. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garrido-Arandia</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murua-García</LastName><ForeName>Amaya</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palacin</LastName><ForeName>Aranzazu</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tordesillas</LastName><ForeName>Leticia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Casado</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanca-Lopez</LastName><ForeName>Natalia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Allergy Service, Hospital Infanta Leonor Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramos</LastName><ForeName>Tania</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Health Research Institute La Princesa (IP) Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canto</LastName><ForeName>Gabriela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Allergy Service, Hospital Infanta Leonor Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Health Research Institute La Princesa (IP) Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuesta-Herranz</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>IIS-Allergy Service, Fundación Jiménez Díaz Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez-Monge</LastName><ForeName>Rosa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pacios</LastName><ForeName>Luis F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain ; Biotechnology Department, ETSI de Montes, Technical University Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díaz Perales</LastName><ForeName>Araceli</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Plant Biotechnology and Genomics U.P.M. - I.N.I.A., Campus de Montegancedo Pozuelo de Alarcón, Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Food Sci Nutr</MedlineTA><NlmUniqueID>101605473</NlmUniqueID><ISSNLinking>2048-7177</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Act d 2</Keyword><Keyword MajorTopicYN="N">N-glycosylation</Keyword><Keyword MajorTopicYN="N">allergen sensitization</Keyword><Keyword MajorTopicYN="N">carbohydrate complex determinant</Keyword><Keyword MajorTopicYN="N">plant food allergy</Keyword><Keyword MajorTopicYN="N">thaumatin-like protein</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>01</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>01</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24936296</ArticleId><ArticleId IdType="doi">10.1002/fsn3.99</ArticleId><ArticleId IdType="pmc">PMC4048612</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Biol Chem. 2011 Apr 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